Dendritic cell-targeted lentiviral vector development

Lentiviral vectors have been highly useful both in research and gene therapy approaches to therapy because of their ability to stably express genes in a wide variety of target cell-types.  However, the vectors don’t work well in DCs because SAMHD1 blocks them.  We devised HIV-1-based lentiviral vectors that package SIV Vpx, thereby overcoming the block to infection.  Our vectors transduce DCs in tissue culture with a two-log increase in titer.  This high efficiency transduction provides a means by which DCs can now be used in gene therapy.

Prof. Nathaniel R. Landau, PhD


Professor, Department of Microbiology


Member of the Microbial Pathogenesis Program

Full Bio.

Department of Microbiology

Alexandria Center for Life Science - West Tower

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