Vectored Immunoprophylaxis of SARS-CoV-2.

Takuya Tada, Julia Minnee and Nathaniel R. Landau. Proceedings of the National Academy of Sciences of the United States of America. 120 (23) e2303509120. https://doi.org/10.1073/pnas.2303509120. 2023.

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Single-epitope T cell-based vaccine protects against SARS-CoV-2 infection in a preclinical animal model.

Tada T, Peng JY, Dcosta BM, Landau NR. JCI Insight 8(7):e167306. 2023.

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Delta-Omicron recombinant escapes therapeutic antibody neutralization

Duerr R, Zhou H, Tada T, Dimartino D, Marier C, Zappile P, Wang G, Plitnick J, Griesemer SB, Girardin R, Machowski J, Bialosuknia S, Lasek-Nesselquist E, Hong SL, Baele G, Dittmann M, Ortigoza MB, Prasad PJ, McDonough K, Landau NR, St George K, Heguy A.

iScience 26(2):106075. 2023.

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Prophylaxis and treatment of SARS-CoV-2 infection by an ACE2 receptor decoy in a preclinical animal model

Takuya Tada, Belinda M Dcosta, Hao Zhou, Nathaniel R Landau. iScience 26 (2) 106092. 2023.

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Engineered multivalent self-assembled binder protein against SARS-CoV-2 RBD 

Britton Dustin, Punia Kamia, Mahmoudinobar Farbod, Tada Takuya, Jiang Xunqing, Renfrew Paul, Bonneau Richard, Landau Nathaniel, Kong Xiangpeng, Montclare Jin. Biochemical Engineering Journal l 187 (2022) 108596. 2022

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Directly injected lentiviral vector-based T cell vaccine protects mice against acute and chronic viral infection 

Takuya Tada, Thomas D. Norton, Rebecca Leibowitz, and Nathaniel R. Landau. JCI Insight 161598. 2022

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Resistance of SARS-CoV-2 Omicron BA.1 and BA.2 Variants to Vaccine-Elicited Sera and Therapeutic Monoclonal Antibodies 

Hao Zhou, Belinda M Dcosta, Nathaniel R Landau, Takuya Tada. Viruses 2022, 14(6), 1334. 2022

 

Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy

Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, Tuo Zhang, Skyler Uhl, Brienne C. Lubor, Vasuretha Chandar, Cristianel Gil, Wei Zhang, Brittany Dodson, Jeroen Bastiaans, Malavika Prabhu, Christine M. Salvatore, Yawei J. Yang, Rebecca N. Baergen, Benjamin R. tenOever, Nathaniel R. Landau, Shuibing Chen, Robert E. Schwartz, Heidi Stuhlmann. iScience 25,
104223, 2022

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Increased resistance of SARS-CoV-2 Omicron Variant to Neutralization by Vaccine-Elicited and Therapeutic Antibodies

Takuya Tada, Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Vidya Chivukula, Ramin S. Herati, Stevan R. Hubbard, Mark J. Mulligan, Nathaniel R. Landau. eBioMedicine 2022;78:103944, 2022

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Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection 

Kyung Ku Jang, Maria E. Kaczmarek, Simone Dallari, Ying-Han Chen, Takuya Tada, Jordan Axelrad, Nathaniel R. Landau, Kenneth A. Stapleford, Ken Cadwell. PLoS Biol 20(3): e3001592, 2022

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High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals

Takuya Tada, Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Amber Cornelius, Ramin S. Herati, Mark J. Mulligan, Nathaniel R. Landau. Cell Reports 38(2).2022

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Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera

Takuya Tada, Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Mark J. Mulligan, Nathaniel R. Landau. iScience 24(11).2021

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High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens

Claudio Counoupas, Paco Pino, Alberto O. Stella, Caroline Ashley, Hannah Lukeman, Nayan D. Bhattacharyya, Takuya Tada, Stephanie Anchisi, Charles Metayer, Jacopo Martinis, Anupriya Aggarwal, Belinda M. Dcosta, Joeri Kint, Maria J Wurm, Nathaniel R. Landau, Megan Steain, Stuart G Turville, Florian M Wurm, Sunil A. David, James A. Triccas. Vaccines 10 (1) e01695-21 . 2022

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B.1.526 SARS-CoV-2 Variants Identified in New York City are Neutralized by Vaccine-Elicited and Therapeutic Monoclonal Antibodies

Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Mark J. Mulligan, Nathaniel R. Landau, Takuya Tada. mBio Volume 12 • Number 4 • 31 August 2021

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Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants

Takuya Tada, Hao Zhou, Marie I. Samanovic, Belinda M. Dcosta, Amber Cornelius, Mark J. Mulligan, Nathaniel R. Landau. Prepint on BioRxiv.

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Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes

Takuya Tada, Belinda M. Dcosta, Marie I. Samanovic, Ramin S. Herati, Amber Cornelius, Hao Zhou, Ada Vaill, Wes Kazmierski, Mark J. Mulligan, Nathaniel R. Landau. mBio 12, Number 3 (June 2021).

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

Johannes F. Scheid, Christopher O. Barnes, Basak Eraslan, Andrew Hudak, Jennifer R. Keeffe, Lisa A. Cosimi, Eric M. Brown, Frauke Muecksch, Yiska Weisblum, Shuting Zhang, Toni Delorey, Ann E. Woolley, Fadi Ghantous, Sung-Moo Park, Devan Phillips, Betsabeh Tusi, Kathryn E. Huey-Tubman, Alexander A. Cohen, Priyanthi N.P. Gnanapragasam, Kara Rzasa, Theodora Hatziioanno, Michael A. Durney, Xiebin Gu, Takuya Tada, Nathaniel R. Landau, Anthony P. West, Orit Rozenblatt-Rosen, Michael S. Seaman, Lindsey R. Baden, Daniel B. Graham, Jacques Deguine, Paul D. Bieniasz, Aviv Regev, Deborah Hung, Pamela J. Bjorkman, Ramnik J. Xavier. Cell, (2021).

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Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities

Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities

Maria G. Noval, Maria E. Kaczmarek,  Akiko Koide, Bruno A. Rodriguez-Rodriguez, Ping Louie, Takuya Tada, Takamitsu Hattori, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Andrew Bazley, Maren de Vries, Marie I. Samanovic, Jeffrey N. Weiser, Ioannis Aifantis, Joan Cangiarella, Mark J. Mulligan, Ludovic Desvignes, Meike Dittmann, Nathaniel R. Landau, Maria Aguero-Rosenfeld, Shohei Koide & Kenneth A. Stapleford. Sci Rep 11, 5538 (2021).

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The ACE2-binding interface of SARS-CoV-2 Spike inherently deflects immune recognition

Takamitsu Hattori, Akiko Koide, Maria G. Noval, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Takuya Tada, Nathaniel R. Landau, Kenneth A. Stapleford, Shohei Koide, Journal of Molecular Biology,Volume 433, Issue 3, (2021),166748.

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An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

Takuya Tada, Chen Fan, Chen Jennifer, Ramanjit Kaur, Kenneth A. Stapleford, Harry Gristick, Belinda M. Dcosta, Craig B. Wilen, Crina Nimigean, Nathaniel R. Landau. Cell Reports (2020) Volume 33, Issue 12, 108528.

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Lentiviral-Vector-Based Dendritic Cell Vaccine Synergizes with Checkpoint Blockade to Clear Chronic Viral Infection

Thomas D. Norton, Takuya Tada, Rebecca Leibowitz, Verena van der Heide, Dirk Homann, Nathaniel R. Landau. Molecular Therapy,
Volume 28, Issue 8, 2020, Pages 1795-1805, 

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Lentiviral vector-based dendritic cell vaccine suppresses HIV replication in humanized mice.

Thomas D. Norton, Anjie Zhen, Takuya Tada, Jennifer Kim, Scott Kitchen, Nathaniel R. Landau. Molecular Therapy (2019), Volume 27, Issue 5, 960 - 973.

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Toll-Like Receptor Agonist R848 Blocks Zika Virus Replication By Inducing The Antiviral Protein Viperin. 

Vanwalscappel, Bénédicte ; Tada, Takuya; Landau, Nathaniel R.  Virology. 2018 09; 522:199-208

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DNA Damage Induces A SAMHD1-Mediated Block To The Infection Of Macrophages By HIV-1. 

Jáuregui, Paula & Landau, Nathaniel. Scientific Reports. 2018 Mar 07; 8(1):4153

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A Highly Active Isoform Of Lentivirus Restriction Factor SAMHD1 In Mouse. 

Bloch, Nicolin; Glasker, Sabine; Sitaram, Poojitha; Hofmann, Henning; Shepard, Caitlin N; Schultz, Megan L; Kim, Baek; Landau, Nathaniel R. Journal Of Biological Chemistry. 2017 01 20; 292(3):1068-1080

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Staphylococcus Aureus Leukocidin LukED And HIV-1 Gp120 Target Different Sequence Determinants On CCR5. 

Tam, Kayan; Schultz, Megan; Reyes-Robles, Tamara; Vanwalscappel, Benedicte; Horton, Joshua; Alonzo, Francis 3rd; Wu, Beili; Landau, Nathaniel R; Torres, Victor J. MBio. 2016 12 13; 7(6):

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IFN-Epsilon Protects Primary Macrophages Against HIV Infection. 

Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan; Chang, Theresa L. JCI Insight. 2016 12 08; 1(20):e88255

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TLR7/8 Agonist Induces A Post-Entry SAMHD1-Independent Block To HIV-1 Infection Of Monocytes. 

Hofmann, Henning; Vanwalscappel, Benedicte; Bloch, Nicolin; Landau, Nathaniel R. Retrovirology. 2016 Dec 01; 13(1):83

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Intrinsic Host Restrictions To HIV-1 And Mechanisms Of Viral Escape.

Simon, Viviana; Bloch, Nicolin; Landau, Nathaniel R. Nature Immunology. 2015 Jun; 16(6):546-53