Neutralization of viruses with European, South African, and United States SARS-CoV-2 variant spike proteins by convalescent sera and BNT162b2 mRNA vaccine-elicited antibodies

Takuya Tada, Belinda M Dcosta, Marie Samanovic-Golden, Ramin S Herati, Amber Cornelius, Mark J Mulligan, Nathaniel R Landau. Preprint in BioRxiv.

A soluble ACE2 microbody protein fused to a single immunoglobulin Fc domain is a potent inhibitor of SARS-CoV-2 infection in cell culture

Takuya Tada, Chen Fan, Chen Jennifer, Ramanjit Kaur, Kenneth A. Stapleford, Harry Gristick, Belinda M. Dcosta, Craig B. Wilen, Crina Nimigean, Nathaniel R. Landau. Cell Reports (2020), 


The ACE2-binding interface of SARS-CoV-2 Spike inherently deflects immune recognition

Takamitsu Hattori, Akiko Koide, Maria G. Noval, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Takuya Tada, Nathaniel R. Landau, Kenneth A. Stapleford, Shohei Koide, Journal of Molecular Biology,Volume 433, Issue 3, (2021),166748,

High titers of multiple antibody isotypes against the SARS-CoV-2 spike receptor-binding domain and nucleoprotein associate with better neutralization.

Maria G. Noval, Maria E. Kaczmarek, Akiko Koide, Bruno A. Rodriguez-Rodriguez, Ping Louie, Takuya Tada, Takamitsu Hattori, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Andrew Bazley, Maren de Vries, Marie I. Samanovic, Jeffrey N. Weiser, Ioannis Aifantis, Joan Cangiarella, Mark J. Mulligan, Ludovic Desvignes, Meike Dittmann, Nathaniel R. Landau, Maria Aguero-Rosenfeld, Shohei Koide, Kenneth A. Stapleford. Preprint in BioRxiv.

Lentiviral vector-based dendritic cell vaccine suppresses HIV replication in humanized mice.

Thomas D. Norton1,2*, Anjie Zhen3*, Takuya Tada1, Jennifer Kim3, Scott Kitchen3*, Nathaniel R. Landau2.

 Molecular Therapy, Volume 27, Issue 5, 960 - 973.

Toll-Like Receptor Agonist R848 Blocks Zika Virus Replication By Inducing The Antiviral Protein Viperin. 

Vanwalscappel, Bénédicte ; Tada, Takuya; Landau, Nathaniel R. 

Virology. 2018 09; 522:199-208

DNA Damage Induces A SAMHD1-Mediated Block To The Infection Of Macrophages By HIV-1. 

Jáuregui, Paula & Landau, Nathaniel. .

Scientific Reports. 2018 Mar 07; 8(1):4153

A Highly Active Isoform Of Lentivirus Restriction Factor SAMHD1 In Mouse. 

Bloch, Nicolin; Glasker, Sabine; Sitaram, Poojitha; Hofmann, Henning; Shepard, Caitlin N; Schultz, Megan L; Kim, Baek; Landau, Nathaniel R.

Journal Of Biological Chemistry. 2017 01 20; 292(3):1068-1080

Staphylococcus Aureus Leukocidin LukED And HIV-1 Gp120 Target Different Sequence Determinants On CCR5. 

Tam, Kayan; Schultz, Megan; Reyes-Robles, Tamara; Vanwalscappel, Benedicte; Horton, Joshua; Alonzo, Francis 3rd; Wu, Beili; Landau, Nathaniel R; Torres, Victor J.

MBio. 2016 12 13; 7(6):

IFN-Epsilon Protects Primary Macrophages Against HIV Infection. 

Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan; Chang, Theresa L.

JCI Insight. 2016 12 08; 1(20):e88255

TLR7/8 Agonist Induces A Post-Entry SAMHD1-Independent Block To HIV-1 Infection Of Monocytes. 

Hofmann, Henning; Vanwalscappel, Benedicte; Bloch, Nicolin; Landau, Nathaniel R.

Retrovirology. 2016 Dec 01; 13(1):83

Intrinsic Host Restrictions To HIV-1 And Mechanisms Of Viral Escape.

Simon, Viviana; Bloch, Nicolin; Landau, Nathaniel R.

Nature Immunology. 2015 Jun; 16(6):546-53

Prof. Nathaniel R. Landau, PhD


Professor, Department of Microbiology


Member of the Microbial Pathogenesis Program

Full Bio.

Department of Microbiology

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