PUBLICATIONS

SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta

Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, Tuo Zhang, Skyler Uhl, Brienne C. Lubor, Vasuretha Chandar, Cristianel Gil, Wei Zhang, Brittany Dodson, Jeroen Bastiaans, Malavika Prabhu, Christine M. Salvatore, Yawei J. Yang, Rebecca N. Baergen, Benjamin R. tenOever, Nathaniel R. Landau, Shuibing Chen, Robert E. Schwartz, Heidi Stuhlmann Preprint in BioRxiv

Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes

Takuya Tada, Belinda M. Dcosta, Marie I. Samanovic, Ramin S. Herati, Amber Cornelius, Hao Zhou, Ada Vaill, Wes Kazmierski, Mark J. Mulligan, Nathaniel R. Landau. mBio 12, Number 3 (June 2021).

The Spike Proteins of SARS-CoV-2 B.1.617 and B.1.618 Variants Identified in India Provide Partial Resistance to Vaccine-elicited and Therapeutic Monoclonal Antibodies

Takuya Tada, Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Mark J. Mulligan, Nathaniel R. Landau. Preprint in BioRxiv.

B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

Johannes F. Scheid, Christopher O. Barnes, Basak Eraslan, Andrew Hudak, Jennifer R. Keeffe, Lisa A. Cosimi, Eric M. Brown, Frauke Muecksch, Yiska Weisblum, Shuting Zhang, Toni Delorey, Ann E. Woolley, Fadi Ghantous, Sung-Moo Park, Devan Phillips, Betsabeh Tusi, Kathryn E. Huey-Tubman, Alexander A. Cohen, Priyanthi N.P. Gnanapragasam, Kara Rzasa, Theodora Hatziioanno, Michael A. Durney, Xiebin Gu, Takuya Tada, Nathaniel R. Landau, Anthony P. West, Orit Rozenblatt-Rosen, Michael S. Seaman, Lindsey R. Baden, Daniel B. Graham, Jacques Deguine, Paul D. Bieniasz, Aviv Regev, Deborah Hung, Pamela J. Bjorkman, Ramnik J. Xavier. Cell, (2021).

B.1.526 SARS-CoV-2 variants identified in New York City are neutralized by vaccine-elicited and therapeutic monoclonal antibodies

Hao Zhou, Belinda M. Dcosta, Marie I. Samanovic, Mark J. Mulligan, Nathaniel R. Landau, Takuya Tada. Preprint in BioRxiv.

Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities

Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities

Maria G. NovalMaria E. Kaczmarek,  Akiko KoideBruno A. Rodriguez-RodriguezPing LouieTakuya TadaTakamitsu HattoriTatyana PanchenkoLarizbeth A. RomeroKai Wen TengAndrew BazleyMaren de VriesMarie I. SamanovicJeffrey N. WeiserIoannis AifantisJoan CangiarellaMark J. MulliganLudovic DesvignesMeike DittmannNathaniel R. LandauMaria Aguero-RosenfeldShohei Koide & Kenneth A. Stapleford. Sci Rep 11, 5538 (2021).

The ACE2-binding interface of SARS-CoV-2 Spike inherently deflects immune recognition

Takamitsu Hattori, Akiko Koide, Maria G. Noval, Tatyana Panchenko, Larizbeth A. Romero, Kai Wen Teng, Takuya Tada, Nathaniel R. Landau, Kenneth A. Stapleford, Shohei Koide, Journal of Molecular Biology,Volume 433, Issue 3, (2021),166748.

An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

Takuya Tada, Chen Fan, Chen Jennifer, Ramanjit Kaur, Kenneth A. Stapleford, Harry Gristick, Belinda M. Dcosta, Craig B. Wilen, Crina Nimigean, Nathaniel R. Landau. Cell Reports (2020) Volume 33, Issue 12, 108528.

Lentiviral-Vector-Based Dendritic Cell Vaccine Synergizes with Checkpoint Blockade to Clear Chronic Viral Infection

Thomas D. Norton, Takuya Tada, Rebecca Leibowitz, Verena van der Heide, Dirk Homann, Nathaniel R. Landau. Molecular Therapy,
Volume 28, Issue 8, 2020, Pages 1795-1805, 

Lentiviral vector-based dendritic cell vaccine suppresses HIV replication in humanized mice.

Thomas D. Norton, Anjie Zhen, Takuya Tada, Jennifer Kim, Scott Kitchen, Nathaniel R. Landau. Molecular Therapy (2019), Volume 27, Issue 5, 960 - 973.

Toll-Like Receptor Agonist R848 Blocks Zika Virus Replication By Inducing The Antiviral Protein Viperin. 

Vanwalscappel, Bénédicte ; Tada, Takuya; Landau, Nathaniel R.  Virology. 2018 09; 522:199-208

DNA Damage Induces A SAMHD1-Mediated Block To The Infection Of Macrophages By HIV-1. 

Jáuregui, Paula & Landau, Nathaniel. Scientific Reports. 2018 Mar 07; 8(1):4153

A Highly Active Isoform Of Lentivirus Restriction Factor SAMHD1 In Mouse. 

Bloch, Nicolin; Glasker, Sabine; Sitaram, Poojitha; Hofmann, Henning; Shepard, Caitlin N; Schultz, Megan L; Kim, Baek; Landau, Nathaniel R. Journal Of Biological Chemistry. 2017 01 20; 292(3):1068-1080

Staphylococcus Aureus Leukocidin LukED And HIV-1 Gp120 Target Different Sequence Determinants On CCR5. 

Tam, Kayan; Schultz, Megan; Reyes-Robles, Tamara; Vanwalscappel, Benedicte; Horton, Joshua; Alonzo, Francis 3rd; Wu, Beili; Landau, Nathaniel R; Torres, Victor J. MBio. 2016 12 13; 7(6):

IFN-Epsilon Protects Primary Macrophages Against HIV Infection. 

Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan; Chang, Theresa L. JCI Insight. 2016 12 08; 1(20):e88255

TLR7/8 Agonist Induces A Post-Entry SAMHD1-Independent Block To HIV-1 Infection Of Monocytes. 

Hofmann, Henning; Vanwalscappel, Benedicte; Bloch, Nicolin; Landau, Nathaniel R. Retrovirology. 2016 Dec 01; 13(1):83

Intrinsic Host Restrictions To HIV-1 And Mechanisms Of Viral Escape.

Simon, Viviana; Bloch, Nicolin; Landau, Nathaniel R. Nature Immunology. 2015 Jun; 16(6):546-53