New Paper in Press!
Lentiviral vector-based dendritic cell vaccine suppresses HIV replication in humanized mice
Thomas D. Norton1,2*, Anjie Zhen3*, Takuya Tada1, Jennifer Kim3, Scott Kitchen3*, Nathaniel R. Landau2 In press. Molecular Therapy.
Norton et al. (2019) report on a gene therapy-based therapeutic dendritic cell vaccine for HIV. The vaccine stimulated a strong HIV-specific CD8 T cell response that suppressed virus load by 100-fold in a humanized mouse model. The approach uses lentiviral vectors that activate dendritic cells and block checkpoint activation.