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New Paper in Press!


Lentiviral vector-based dendritic cell vaccine suppresses HIV replication in humanized mice

Thomas D. Norton1,2*, Anjie Zhen3*, Takuya Tada1, Jennifer Kim3, Scott Kitchen3*, Nathaniel R. Landau2 In press.  Molecular Therapy.


Norton et al. (2019) report on a gene therapy-based therapeutic dendritic cell vaccine for HIV. The vaccine stimulated a strong HIV-specific CD8 T cell response that suppressed virus load by 100-fold in a humanized mouse model. The approach uses lentiviral vectors that activate dendritic cells and block checkpoint activation.


Department of Microbiology

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Prof. Nathaniel R. Landau, PhD

 

Professor, Department of Microbiology

 

Member of the Microbial Pathogenesis Program

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